目的 探讨个性化针对性护理干预在老年慢性阻塞性肺疾病稳定期患者中的应用效果及对微小RNA-146a、微小RNA-146b的影响.方法 选取2021年1月—2022年12月收治的80例老年慢性阻塞性肺疾病稳定期患者作为研究对象,按照组间基线资料可比的原则将其分对照组和观察组,各40例.对照组接受常规护理,观察组在对照组基础上接受综合护理干预,比较两组患者负性情绪、肺功能指标、微小RNA-146a、微小RNA-146b、睡眠质量等.结果 护理干预前,两组患者SAS、SDS评分比较差异无统计学意义(P＞0.05);护理干预后,观察组SAS、SDS评分低于对照组,差异有统计学意义(P＜0.05).护理干预后,观察组用力肺活量(forced vital capacity,FVC)、第1秒用力呼气量(forced ecpiratory volume in the first second,FEV1)、FEV1/FVC 高于对照组,差异有统计学意义(P＜0.05);观察组患者情感负担、经济负担、照顾负担评分低于对照组,差异有统计学意义(P＜0.05);观察组患者匹兹堡睡眠质量量表(Pittsburgh sleep quality scale,PSQI)低于对照组,差异有统计学意义(P＜0.05);护理干预后,观察组患者miR-146a及miR-146b水平高于对照组,差异有统计学意义(P＜0.05).结论 慢性阻塞性肺疾病稳定期患者接受综合护理干预,能让其保持积极心态接受诊治,降低其自我感受负担,改善肺功能,保持良好的睡眠质量.
Effect of individualize targeted nursing interventions on elderly patients with stable COPD
Objective To explore the application effect of individualize targeted nursing intervention in elderly patients with stable chronic obstructive pulmonary disease and the effect on microRNA146a and microRNA-146b.Methods 80 elderly patients with stable chronic obstructive pulmonarydisease admitted from January 2021 to December 2022 were selected as the study objects,they were divided into a control group and an observation group according to the principle of comparable baseline data between groups,with 40 cases in each group.The control group received routine care,and the observation group received individualize targeted nursing intervention on the basis of the control group.Negative emotions,lung function indicators,micro RNA-146a,micro RNA-146b,sleep quality,etc.were compared between the two groups.Results Before the nursing intervention,there was no statistically significant difference between the SAS and SDS scores of the two groups(P＞0.05).After the nursing intervention,the SAS and SDS scores of the observation group were lower than that of the control group,and the difference was statistically significant(P＜0.05).After the nursing intervention,the observation group had a higherforced vital capacity(FVC),forced ecpiratory volume in the first second(FEV1),and FEV1/FVC than the control group,and the difference was statistically significant(P＜0.05);the observation group had a lower emotional burden,economic burden,and care burden score than the control group,and the difference was statistically significant(P＜0.05).The observation group had a lower Pittsburgh sleep quality scale(PSQI)than the control group,and the difference was statistically significant(P＜0.05);After the nursing intervention,the observation group had mi R-146a and miR-146b levels of the intervention control group,the difference was statistically significant(P＜0.05).Conclusion Individualize targeted nursing intervention for patients with stable chronic obstructive pulmonary disease can maintain a positive attitude to accept the treatment,reduce their self-feeling burden,improve lung function,maintain good sleep quality.
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