Objective To explore the effect of evidence-based nursing on preventing surgical site infections among patients after cardiac surgery.Methods A total of 100 patients treated in the cardiac surgery department of the First Affiliated Hospital of Shandong First Medical University from February to August 2023 were selected as the study subjects.According to the principle of comparability of inter-group baseline data,they were divided into a control group and an observation group,with 50 cases in each group.The control group implemented routine nursing care,while the observation group implemented evidence-based nursing.The differences in postoperative wound healing and clinical indicators between the two groups were compared.hemoglobin(Hb),white blood cell(WBC)count,and neutrophils(N)were also compared.The Kolcaba General Comfort Questionnaire(GCQ)was used to assess the physical and psychological comfort of both groups before and 7 days after intervention.Results After evidence-based nursing intervention,the degree of wound healing in the observation group was better than that in the control group,the operation duration,wound recovery time,duration of antibiotic use,and hospital stay of the observation group were all shorter than those of the control group,the differences were statistically significant(P<0.05).Before implementing evidence-based nursing,there was no statistically significant difference in values of Hb,WBC,N and GCQ scores between the two groups(P>0.05).After the intervention,the WBC and N values of the observation group were lower than those of the control group,the Hb value and GCQ score were higher than those of the control group,and the differences were statistically significant(P<0.05).Conclusion Evidence-based nursing has a high application value in preventing surgical site infections after cardiac surgery.It not only effectively prevents postoperative wound infections but also accelerates wound healing,which is of great significance in strengthening the surgical treatment outcomes and improving physical and psychological comfort for patients.