Determination of 47 Drugs from 11 Categories in Soil by UPLC-MS/MS Combined with QuEChERS
In this study,a UPLC-MS/MS method combined with QuEChERS was established to simultaneously determine 47 drugs from 11 categories in soil,separation effects of different columns and mobile phases on the analytes were addressed,and extraction effects of EDTA-Mcllvaine buffer solution with different pH and purification effects of d-SPE dispersers on drugs were also analyzed.The results showed that all the 47 drugs showed good linearity with r≥0.995,LODs of 47 compounds ranged from 0.1 to 2.5 μg/kg,LOQs ranged from 0.5 to 8 μg/kg,recoveries varied between 61.1%and 117.0%,and RSDs from 1.9%to 11.4%.This UPLC-MS/MS method is sensitive and suitable for accurate and high throughput analysis of multiclass drugs residues in soil.Thus,it is useful for analysis of occurrence characteristics and risk assessment of drugs residues in soil.
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