Chemical Constituents and Anti-inflammatory Activities of a Streptosporangium hygroscopicus n.sp.
To study the chemical constituents and the inflammatory activities of the cultured filaments of a Streptosporangium hygroscopicus n.sp..Several chromatographic methods were used to separate the chemical constituents,of which structures were identified by NMR,IR and MS.The anti-inflammatory activities of compounds 1,2,4 and 5 were observed in rats with carrageenin-induced toe swelling experiments.Five compounds have been isolated from the Streptosporangium hygroscopicus n.sp..Their structures were identified as formononetin(1),N-acetyl-2-(4-hydroxxy phen yl)-ethylamine (2),fumalic acid (3),3,4,5-trimethyl-1,2-benzenediol (4),7,3'-dihydroxy-4'-methoxyflavone (5).Compounds 1,2,4 and 5 could inhibit carrageenin-induced toe swelling in rats at 15 mg/(kg · d),The inhibition ratio was 47.3％,16.8％,13.6％ and 50.4％.Compounds 1、4 and 5 were isolated from this streptosporangium sp for the first time.Compound 1 and 5 possess strong anti-inflammatory activities.
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