This study aimed to investigate the chemical composition,antioxidant,enzyme inhibitory,and anti-inflammatory ac-tivities of Hedychium flavum flower extracts.H.flavum flower water extracts and ethanol extracts were obtained by reflux ex-traction method.The chemical composition of the extracts was identified by ultra-high-performance liquid chromatography cou-pled to quadrupole-orbitrap mass spectrometry(UHPLC-Q-Orbitrap-MS).A total of 58 compounds were identified,including 11 phenols and 18 flavonoids.The extracts showed strong antioxidant activity in the DPPH and ABTS assay and had certain inhibitory effects on α-glucosidase,tyrosinase,acetylcholinesterase,and butyrylcholinesterase.Within the non-toxic dose range(62.5,125,250 µg/mL),the extracts significantly reduced LPS-induced oversecretion of pro-inflammatory mediators(NO and PGE2)and cytokines(TNF-α,IL-6,IL-1β)in RAW 264.7 cells.Our study provides a theoretical basis for the develop-ment and utilization of H.flavum flower in the food,pharmaceutical,and cosmetic industries.
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