Chemical constituents from Selaginella prostrata H.S.Kung and their α-glucosidase inhibitory activities
This paper aims to study the chemical constituents of Selaginella prostrata H.S.Kung and their α-glucosidase in-hibitory activity.A new sesquiterpene,namely seprostrataoid A(1),together with nine known compounds,namely(3S,5R,8S)-5,8-epoxy-6-megastigmadien-3,9-diol(2),(-)-loliolide(3),(3S,5R,6R,7E)-3,5,6-trihydroxy-7-megastigmen-9-one(4),(7 R,8S)-ceplignan(5),(2R,3S)-dihydro-2-(3',5'-dimethoxy-4'-hydroxyphenyl)-7-methoxy-5-acetyl-benzofuran(6),5,5'-dimethoxylclemaphenol A(7),amentoflavone(8),isocryptomerin(9),hinokiflavone(10),were isolated and pu-rified from the 95％ethanol extract of S.prostrata by comprehensive chromatography methods of silica gel column,Sephadex LH-20 gel column and semi-preparative HPLC.All compounds are obtained from S.prostrata for the first time.In vitro activity results showed that compounds 7-10 had significant α-glucosidase inhibitory activity with IC50 values of 72.14±2.67,42.68 ±1.54,61.26±4.32 and 55.43±2.17 μmol/L,respectively.
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