In order to search for fungal metabolites with various structures and cytotoxic activities,the metabolites of Trichothe-cium roseum solid fermentation were isolated and purified by various chromatographic techniques.Five diterpenoids were ob-tained from the fermentation broth of Trichothecium roseum,their structures were identified as one new diterpene compound,melanocane F(1)and four known compounds,rosenonolactone(2),desoxyrosenonolactone(3),rosonolactone(4)and 2α-hydroxyisocupressic acid(5)by the analysis of spectroscopic data including HR-ESI-MS,1H NMR and 13C NMR.All com-pounds were evaluated for their cytotoxic activity on MCF-7 cells.As a result,compounds 1 and 5 showed the most significant inhibitory activity on MCF-7 cells.
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