A new gemmarane-type sesquiterpenoid from Chrysanthemum indicum L.
To study the chemical constituents of the aboveground of Chrysanthemum indicum L.All compounds were separated and purified by MCI,ODS,SephadexLH-20 gel column chromatography and pre-HPLC,and the structures of them were identi-fied by analyzing of their spectroscopic data.Compounds 1-6 were isolated from the dichloromethane extract of C.indicum,which were identified as chrygermalide A(1),3β-hydroxy-oxo-7α,11β-germacra-4Z,10(14)-diene-12,6α-olide(2),deacetylherbolide A(3),9β-hydroxy costunolide(4),3β-hydroxycostunolide(5),3β-hydroxy-11α,13-dihydrocos-tunolide(6).Compound 1 is a new compound,and 2-6 are isolated from this genus for the first time.The anti-inflammatory activity of compounds 1-6 were tested in LPS-induced RAW 264.7 macrophage cells,and the IC50 values of their NO release inhibition were 17.9-33.9 μmol/L.
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