摘要
鬼箭羽始载于《神农本草经》,列为中品,具有通经、破血、杀虫和散瘀止痛等功效.现代药理学研究表明其具有降血糖、抗肿瘤、抗炎镇痛、抗菌、抗氧化、抗病毒等药理作用,其活性成分以黄酮类和萜类成分为主.本文通过对鬼箭羽的化学成分、药理作用、毒理等方面进行综述,并基于此,从植物亲缘关系、化学成分有效性、化学成分可测性等方面对鬼箭羽的质量标志物进行推测分析,初步预测芦丁、槲皮素、香橙素、儿茶素、β-谷甾醇、鬼箭羽二萜A和11-羰基-β-乳香酸等成分可作为鬼箭羽潜在的质量标志物,以期为鬼箭羽的质量控制和临床用药规范提供科学依据.
Abstract
Euonymus alatus(Thunb.)Siebold is considered as the wing-like appendage or wing-like branch,which was first recorded in the Shennong's Herbal Classic,is classified as a middle-grade herb with the effects of promoting blood circulation,dispelling blood stasis,killing parasites,and relieving pain.Modern pharmacological studies have shown that it has pharmaco-logical effects such as lowering blood glucose,anti-tumor,anti-inflammatory,analgesic,antibacterial,antioxidant,and antiviral effects,and its active ingredients are rich,and most of the current studies are focused on the flavonoid and terpenoid com-pounds.This article provides a comprehensive review of the chemical composition,pharmacological effects,toxicity,and other aspects of E.alatus.Based on the plant's phylogenetic relationship,the effectiveness of its chemical components,and the de-tectability of its chemical composition,speculations and analyses are made on the potential quality markers(Q-Marker)of E.alatus.It is preliminarily predicted that components such as rutin,quercetin,hesperidin,catechins,β-sitosterol,euonymuditer-pene A,11-keto-β-boswellic acid,etc.can be potential quality markers of E.alatus.This review aims to provide scientific evi-dence for the quality control and standardized clinical use of E.alatus.
基金项目
国家重点研发计划(2020YFE0201800)
河南省高校科技创新人才项目(23HASTIT044)
河南省科技攻关项目(232102310447)
河南省高校科技创新团队项目(21IRTSTHN026)
国家科技期刊平台
NSTL
万方数据