Chemical constituents and anti-inflammatory activity of Talaromyces sp.W21 from Huixian Wetland in Guilin
This study aims to investigate the chemical constituents and anti-inflammatory activity of Talaromyces sp.W21 from the Huixian wetland in Guilin.A new α-pyrone derivative,namely cytospone K(1),together with nine known compounds,namely(3S,4R,5R)-4-hydroxymethyl-3,5-dimethyldihydro-2-furanone(2),lasdiplactone(3),leptosphaerone C(4),annu-larin A(5),annularin K(6),cladobotrin V(7),2-(2'S-hydroxypropyl)-5-methyl-7-hydroxychromone(8),bacillisporin A(9)and bacillisporin B(10)were isolated and purified from cultures of Talaromyces sp.W21 by using various column chromatography.Their structures were identified by modern spectroscopic techniques and physicochemical properties.Com-pound 1 was a new α-pyranone derivative,and compounds 2-8 were isolated from the Talaromyces sp.for the first time.The anti-inflammatory activity assay showed that compounds 9 and 10 have a moderate inhibition of NO production induced by LPS in RAW 264.7 cells,with IC50 values of 38.90±0.79 and 35.02±1.03 µmol/L respectively.
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