天然产物研究与开发2024,Vol.36Issue(8) :1445-1455.DOI:10.16333/j.1001-6880.2024.8.018

松果菊苷药理作用及机制的研究进展

Research progress on the pharmacological action and mechanism of echinacoside

孙悦 包旭宏 刘文伟 张国霞
天然产物研究与开发2024,Vol.36Issue(8) :1445-1455.DOI:10.16333/j.1001-6880.2024.8.018

松果菊苷药理作用及机制的研究进展

Research progress on the pharmacological action and mechanism of echinacoside

孙悦 1包旭宏 2刘文伟 3张国霞3
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作者信息

  • 1. 甘肃中医药大学
  • 2. 甘肃省中药现代制药工程研究院;甘肃奇正藏药有限公司,兰州 730000
  • 3. 甘肃省中药现代制药工程研究院
  • 折叠

摘要

松果菊苷(echinacoside,ECH)为苯乙醇苷类化合物,存在于多种植物中,为极具潜力的中药成分,应用前景广阔.现代药理研究表明ECH具有许多的生物学效应,如神经保护作用、心肌保护作用、肝脏保护作用、抗肿瘤、抗氧化抗衰老,同时还有免疫调节、降糖降脂、促进生殖和骨形成、保护肺血管以及预防动脉粥样硬化等药理作用,可用于多个系统疾病的治疗,对其进行药效机制的进一步探究和开发具有重要意义.因此,该文就近几年来对ECH的药理作用及作用机制研究进行了归纳总结,并对其研究现状及未来方向提出了建议,以期为其进一步深入研究及开发利用提供一定的参考价值.

Abstract

Echinacoside(ECH)is a phenylethanol glycoside compound that exists in a variety of plants and is a promising tra-ditional Chinese medicine ingredient with broad application prospects.Modem pharmacological studies have shown that ECH has many biological effects,such as neuroprotective,myocardial protective,liver protective,anti-tumor,antioxidant anti-aging,as well as immunomodulation,hypoglycemic and lipid reduction,promotion of reproduction and bone formation,protection of pulmonary blood vessels and prevention of atherosclerosis and other pharmacological effects,which can be used for the treat-ment of multiple system diseases,and the further exploration and development of its pharmacodynamic mechanism is of great significance.Therefore,this paper summarizes the pharmacological effects and mechanism of ECH in recent years,and puts forward suggestions on its research status and future direction,in order to provide some reference for its further in-depth re-search,development and utilization.

关键词

松果菊苷/药理作用/作用机制

Key words

echinacoside/pharmacological action/mechanism of action

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基金项目

国家重点研发计划(2022YFC3502203)

出版年

2024
天然产物研究与开发
中国科学院成都文献情报中心

天然产物研究与开发

CSTPCD北大核心
影响因子:0.783
ISSN:1001-6880
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