Chemical constituents from Fallopia cynanchoides(Hemsl.)Harald.var.cynanchoides
To study the chemical constituents of the whole plant of Fallopia cynanchoides(Hemsl.)Harald.var.cynanch-oides,seventeen compounds were isolated and purified by various modern chromatographic techniques,including normal phase and reverse phase silica gel column chromatography,Sephadex LH-20 column chromatography,semi-preparative HPLC.NMR,MS and other related spectroscopic analyses were used to identify their structures.The isolated compounds were identified as lyoniresinol(1),β-D-(1-O-acetyl-3,6-O-trans-diferuloyl)-fructofuranosyl-α-D-2',4',6'-O-triacetylglucopyranoside(2),p-hydroxyphenethyl trans-ferulate(3),(3S,5R,6S,7 E)-3,5,6-trihydroxy-7-megastigmen-9-one(4),2,3-dihydroxy-1-(4-hy-droxy-3,5-dimethoxyphenyl)-1-propanone(5),2-methyl-5-(2'-oxo-4'-hydroxypentyl)-7-hydroxychromone(6),2-(2'-hydroxypropyl)-5-methyl-7-hydroxychromone(7),2,5-dimethyl-7-hydroxychromone(8),2-methyl-5-acetonyl-7-hydroxy-chromone(9),emodin(10),quercetin(11),(+)-taxifolin(12),3,7-dimethoxy-5,3',4'-trihydroxy-flavone(13),caffeic acid methyl ester(14),protocatechuic acid ethyl ester(15),(2aS,3aS)-lyciumamide D(16),and 3-acetyl-4,5-dimethoxy-benzoic acid(17).This was the first report of the presernce of compounds 1-7,9,13,14,16,and 17 in the genus Fallopia.Compounds 1-9 and 11-17 were first identified from F.cynanchoides var.cynanchoides.The 70％ethanol extract showed obvi-ous ABTS+radicals scavenging effect with IC50 value of 14.21 μg/mL;further in vitro bioassay indicated that compounds 1-3,11,13-17 showed moderate ABTS+radicals scavenging activities.Among them,compounds 1,13,14 demonstrated significant antioxidant effects with IC50 values of 15.30,16.97 and 17.53 μmol/L,which were better than that of positive medicine trolox(IC50 23.55 μmol/L).These findings provided an important foundation for the development and utilization of plant resource of F.cynanchoides var.cynanchoides.
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