Study on the compounds with α-glucosidase inhibitory activity from leaves of Ficus esquiroliana
This study aims to investigate the chemical constituents from the leaves Ficus equiroliana H.Lév,together with theirα-glucosidase inhibitory activities.Nine compounds were isolated and purified from the 95％ethanol extract of the title plant by using systematic separation methods,including silica gel,ODS,Sephadex LH-20 column chromatography and semi-prepara-tive liquid chromatography.Their structures were identified as N-trans-ferulic-L-proline methyl ester(1),N-p-coumaroyltyra-mine(2),3',4',5'-trimethoxycinnamyl alcohol(3),lcariside H1(4),(-)-dendrolactone(5),3-hydroxy-1-(4-hydroxy-3,5-dimethoxyphenyl)-1-propanone(6),trans-ferulic acid(7),sinapyl alcohol(8)and(E)-p-coumaric acid(9)by NMR and HR-ESI-MS.Compound 1 is a new compound,compounds 2-6 and 8 were isolated for the first time from the leaves of F.equi-roliana.Compounds 1-6 and 8 showed α-glucosidase inhibitory activities with IC50 values of 76.25-263.18 μmol/L.
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