Research progress on the role of renin-angiotensin system in atrial fibrillation
Atrial fibrillation(AF)is the most common arrhythmia and one of the leading causes of stroke,heart disease and death.Although the specific mechanism of AF is still unclear,atrial electrical remodeling and structural remodeling are the main mechanisms which can trigger AF.Recent studies have shown that the renin-angiotensin system(RAS)plays a key role in this remodeling.So far,antiarrhythmic drugs and radiofrequency ablation have not cured AF successfully.Therefore,a prevention strategy is urgently needed to reduce AF-related morbidity,mortality,and healthcare costs.RAS blockers,including angiotensin-converting enzyme inhibitors(ACEIs)and angiotensin-receptor blockers(ARBs),which are the first-line treatment for heart disease.This study found that ACEIs/ARBs can improve cardiac remodeling in patients with AF and can prevent and treat AF.This review describes the role of RAS in the pathogenesis of AF and the potential of RAS blockers in the primary and secondary prevention of AF,in order to provide more ideas for the treatment of AF.
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