Relationship of FGF-21,IMA and MCP-1 with the prognosis of patients with acute myocardial infarction
Objective:To study the relationship of fibroblast growth factor 21(FGF-21),ischemia modified albumin(IMA)and monocyte chemoattractant protein-1(MCP-1)with the prognosis of patients with acute myocardial infarction(AMI).Methods:A total of 110 patients with AMI were admitted to the hospital between May 2017 and July 2020.They were divided into poor prognosis group and good prognosis group according to the prognosis.The clinical data of the patients enrolled were collected,and the levels of serum FGF-21,IMA and MCP-1 were detected.The relationship between the above-mentioned serum indicators and the prognosis of patients with AMI,and the efficiency in diagnosing major adverse cardiovascular event(MACE)were analyzed.Results:The levels of serum FGF-21,IMA and MCP-1 in the good prognosis group were significantly lower than those in the poor prognosis group(P<0.05).The area under the ROC curve(AUC)and sensitivity of the combination of serum FGF-21,IMA and MCP-1 for prognosis were the highest(P<0.05).The incidence of MACE showed statistically significant differences between patients with different levels of serum FGF-21,IMA and MCP-1(P<0.05).Cox univariate analysis and multivariate analysis found that FGF-21 level>150.12 ng/L,IMA level>75.78 U/ml,MCP-1 level>49.67pg/ml,CK-MB level>35 U/L and cTnⅠlevel>75.78 U/ml were independent risk factors for poor prognosis of patients with AMI(P<0.05).Conclusion:The levels of serum FGF-21,IMA and MCP-1 can be used to better predict the occurrence of poor prognosis in patients with AMI,and the combination of the three has higher predictive efficiency.Meanwhile,high levels of serum FGF-21,IMA and MCP-1 are closely related to the occurrence of MACE,which indicates that they are risk factors for poor prognosis of patients with AMI.
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