Correlation between vascular endothelial growth factor and reactive cutaneous capillary endothelial proliferation of advanced non-squamous non-small cell lung cancer patients treated with camrelizumab
Objective:To investigate the predictive effect of the vascular endothelial growth factor(VEGF)in circulating blood on reactive cutaneous capillary endothelial proliferation(RCCEP)induced by camrelizumab treatment in patients with advanced non-squamous non-small cell lung cancer.Methods:A retrospective analysis was conducted on 64 patients with advanced nsNSCLC who were treated with camrelizumab(SHR-1210)and tested for VEGF in the First Affiliated Hospital of Wannan Medical College.Forty-six patients who experienced RCCEP after treatment were divided into Group A,and 18 patients that did not experience RCCEP were divided into Group B.The treatment efficiency and the normal rate of VEGF were compared between the two groups.Moreover,the predictive effect of VEGF on the occurrence of RCCEP,and the correlation between the level of VEGF and the grade of RCCEP were analyzed.Results:Both ORR and DCR in Group A were higher than those in Group B,but the difference was not statistically significant(P>0.05).The number of patients with abnormal VEGF values in Group A was significantly larger than that in Group B(P<0.001).The AUC of the numerical prediction of VEGF for RCCEP was 0.908.The sensitivity was 80.4%,and the specificity was 83.3%.The misdiagnosis rate was 16.7%,the missed diagnosis rate was 19.6%,and the Youden index was 63.7%.VEGF level and RCCEP grade showed a positive correlation(rs = 0.806,P<0.001).Conclusion:The incidence of abnormal VEGF values in patients with RCCEP caused by the treatment of camrelizumab is higher.The level of VEGF has a predictive effect on the occurrence of RCCEP,and its sensitivity and specificity are high.And the RCCEP grade increases with the increase of VEGF value.
万方数据
维普
