Correlation analysis between selective circulation markers and prognosis of glioma
Glioma is the most common malignant primary tumor in the brain.Although great progress has made in surgical resection,immunotherapy and molecular targeted therapy for the treatment of glioma in recent years,the long-term survival prognosis of glioma patients is still poor,and it is particularly critical to explore safe and accurate biological markers for predicting the poor prognosis of glioma patients.Inflammatory prognostic markers,such as neutrophil to lymphocyte ratio(NLR)and prognostic nutritional index(PNI),platelet-to-Lymphocyte ratio(PLR),D-dimer,have been reported in a variety of malignancies.In addition,several scoring systems based on circulating blood cell counts and clotting have been reported to predict the prognosis of cancer patients,such as systemic inflammation score(SIS)and Von willebrand factor antigen(von willebrand factor antigen VWFAg).The best biomarkers and the best cutoff values of the markers can predict different cancer types.In this review,we summarize the prognostic effects of inflammation-related markers in glioma patients,especially glioblastoma(GBM)patients,aiming to provide new ideas for clinical diagnosis and treatment and prognostic judgment of patients.
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