Clinical pathological and prognostic significance of PD-L1 expression in lung adenocarcinoma in bioinformatics
Objective:To evaluate the clinical pathological and prognostic significance of PD-L1 expression in lung adenocarcinoma with bioinformatics,and to validate its expression and clinical pathology with immunohistochemistry.Methods:Using the GEPIA database to analyze the quantitative expression of PD-L1 mRNA in the database,and validate it with immunohistochemical methods;Using Te Kaplan Meier Plotter to evaluate the impact of PD-L1 expression on the prognostic value of lung adenocarcinoma;Analyzing immune cell infiltration in lung adenocarcinoma with Timer2.0;Differential analysis of the expression of different subtypes of PD-L1 in lung adenocarcinoma was performed by the TCGA module of the UALCAN database.Results:Bioinformatics showed that the expression of PD-L1 in cancer tissue was significantly lower than that in normal tissue.Immunohistochemical results showed that PD-L1 was highly expressed in lung adenocarcinoma tissue,but low or no expression was observed in adjacent tissues.The expression of PD-L1 was not significantly different by age,sex,clinical stage and lymph node metastasis,but its expression was significantly correlated with the overall survival OS and first progressive survival FP of patients.Conclusion:PD-L1 expression affects the survival prognosis of lung adenocarcinoma patients.
NETL
NSTL
万方数据
维普
