摘要
目的 通过Meta分析探讨低频重复经颅磁刺激治疗卒中后失语的临床疗效.方法 从数据库建立到2023年10月,检索中国知网、中国生物医学文献数据库、万方数据库、维普数据库、PubMed、Cochrane Library、Embase、Web of Science 8个文献数据库中关于经颅磁刺激治疗卒中后失语的文章.筛选文献后,使用Revman 5.4软件进行Meta分析.结果 纳入7项随机对照试验,共258例患者.结果 显示,接受低频重复经颅磁刺激后,干预组的CCAT评分优于对照组(MD = 1.50,95%CI:1.046～1.960,P<0.001),其中,对话(MD = 1.62,95%CI:0.60～2.63,P = 0.002),描述(MD = 1.86,95%CI:1.30～2.42,P<0.001),表达(MD = 2.54,95%CI:1.96～3.12,P<0.001),重复(MD = 0.99,95%CI:0.45～1.52,P<0.001),自发书写(MD = 1.28,95%CI:0.81～1.75,P<0.001),匹配(MD =-0.41,95%CI:-0.74～-0.08,P = 0.01).西方失语症测验(western aphasia battery,WAB)量表得分差异无统计学意义(MD =-2.44,95%CI:-25.33～20.45,P = 0.83).结论 低频重复经颅磁刺激可有效改善卒中后失语患者的对话、描述、表达、重复、自发书写等方面的语言功能.
Abstract
Objective:To investigate the clinical efficacy of low-frequency repetitive transcranial magnetic stimulation in the treatment of aphasia after stroke through Meta-analysis.Methods:From the establishment of the database to October 2023,articles on transcranial magnetic stimulation in the treatment of aphasia after stroke were searched from eight literature databases:CNKI,China Biomedical Literature Database,Wanfang Database,VIP database,PubMed,Cochrane Library,Embase and Web of Science.After literature screening,Meta-analysis was performed using Revman5.4 software.Results:A total of seven randomized controlled trials were included,involving 258 patients.Results:Meta-analysis showed that the CCAT score of the intervention group was better than that of the control group after receiving low-frequency repetitive transcranial magnetic stimulation(MD = 1.50,95%CI:1.046,1.960,P<0.001),among which,session(MD = 1.62,95%CI:0.60,2.63,P = 0.002).Description(MD = 1.86,95%CI:1.30,2.42,P<0.001),(MD = 2.54,95%CI:1.96,3.12,P<0.001),repeat(MD = 0.99,95%CI:0.45,1.52,P<0.001),spontaneous writing(MD = 1.28,95%CI:0.81,1.75,P<0.001),match(MD =-0.41,95%CI:-0.74,-0.08,P = 0.01).WAB-AQ score no statistical significance(MD =-2.44,95%CI:-25.33,20.45,P = 0.83).Conclusion:Low-frequency repetitive transcranial magnetic stimulation can effectively improve the speech function of patients with aphasia after stroke in terms of conversation,description,expression,repetition and spontaneous writing.
基金项目
国家自然科学基金(82004495)
山东省自然科学基金(ZR2020QH318)
中国博士后科学基金(2021M691985)
济南市科技局临床医学科技创新计划(202225002)
山东省"泰山学者"青年专家基金(tsqn202211349)
山东省医药卫生科技发展计划(202220010816)
NETL
NSTL
维普
万方数据