Effect of low oxygen environment on trophoblast cell in early gestation
Pregnancy is well recognized as a complex physiological process.Qxygen levels in the placental microenvironment throughout gestation are not constant,while early placental formation occurs under a physiological hypoxia environment.This low oxygen condition intersect with the most critical stages of placental development,i.e.,blastocyst implantation,cytotrophoblast invasion and spiral artery remodeling initiation.Disharmony of any step in early gestation will result in adverse pregnancy outcomes.In this review,we aim to highlight how oxygen levels in early placental development determine the survival,fate and function of trophoblast cells arising from the fetus.Understanding the roles of physiological hypoxia in early placental development will provide insights into the root cause of some pregnancy disorders,such as spontaneous abortion,preeclampsia and intrauterine growth restriction.
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NSTL
万方数据
维普
