Research progress on the mechanism of pyroptosis and its relationship with gastric cancer
Pyroptosis is a form of cell death that is essential for immunity.It can be induced by the typical inflammatory vesicles of cysteinyl asparagin1(caspase1)or by cytoplasmic lipopolysaccharide(LPS)activating cysteinyl asparagin4,cysteinyl asparagin5 and cysteinyl asparagin11(caspase4,caspase5,and caspase11).The activated caspase cleaves members of the gasdermin(GSDM)protein family,and the cleaved N-terminal fragments can pore in the cell membrane,resulting in cell pyroptosis,accompanied by the activation and release of inflammatory factors in this process.Recently,members of the GSDM family have been extensively studied,and the study of pyroptosis has also been deepening.The discovery that drugs can induce pyroptosis in gastric cancer cells provides new perspectives for the chemotherapy of gastric cancer.Pyroptosis induces tumor cell death and the accompanying inflammatory response exacerbates its death,but this inflammatory response may be a double-edged sword,and the over-activation of the inflammatory response can promote the development of tumor cells.Therefore,this article reviews the mechanism of pyroptosis and its effect in gastric cancer development,aiming to provide ideas for the development of new pyroptosis-based drugs for gastric cancer patients.
NETL
NSTL
万方数据
维普
