Research progress of liquid biopsy in multiple myeloma
Multiple myeloma(MM)is the second most common hematological malignancy,accounting for about 10%of hematological malignancies.The characteristic of MM is a patchy tumor infiltration pattern in the bone marrow,with occasional extramedullary dissemination.In other words,bone marrow aspirates collected from a single site usually cannot provide a comprehensive genetic profile of the tumor,and bone marrow cannot be repeatedly aspirated.Liquid biopsy(LB)has the characteristics of being non-invasive,dynamic,repeatable,and low-risk,and it has excellent clinical application prospects in tumor diagnosis,progression,treatment efficacy,prognosis,and other aspects.At present,the detection of multiple myeloma mostly uses bone marrow aspiration smear,which will cause trauma to patients and cannot dynamically monitor the efficacy of drugs in patients and has certain limitations.This article elaborates on the application of LB in the diagnosis,treatment,and prognosis evaluation of MM.
NETL
NSTL
万方数据
维普
