肠道菌群及代谢物对代谢功能障碍相关脂肪性肝病的影响
Effects of gut microbiome and metabolites on metabolic dysfunction associated fatty liver disease
张丹芃 1杨鹏 2杨正武2
作者信息
- 1. 山东第一医科大学(山东省医学科学院)研究生部,山东 济南 250117
- 2. 山东第一医科大学第二附属医院消化内科,山东 泰安 271000
- 折叠
摘要
2020年国际专家小组建议将非酒精性脂肪性肝病更名为代谢功能障碍相关脂肪性肝病(metabolic dysfunction associated fatty liver disease,MAFLD),并提出一套新的诊断标准.MAFLD的病理生理机制涉及环境、遗传、代谢以及肠道微生物等多种因素.肠道微生物来源的代谢物可能在MAFLD的发生发展中发挥重要作用.本文对胆汁酸、短链脂肪酸、色氨酸、胆碱、内毒素和乙醇作为肠道菌群代谢物导致MAFLD发展的机制以及相关治疗进展进行综述.
Abstract
In 2020 an international panel of experts recommended that non-alcoholic fatty liver disease be renamed metabolic dysfunction associated fatty liver disease(MAFLD)and proposed a new set of positive diagnostic criteria.The pathophysiology of MAFLD involves a variety of factors such as environment,genetics,metabolism,and gut microbiome.Microbe-derived metabolites may play an important role in the development of MAFLD.This article reviews the mechanisms of bile acids,short-chain fatty acids,tryptophan,choline,endotoxin,and ethanol as gut microbiota metabolites leading to the development of MAFLD and related treatment progress.
关键词
肠道菌群/代谢相关脂肪性肝病/胆汁酸/益生菌/粪菌移植Key words
gut microbiome/metabolic dysfunction associated fatty liver disease/bile acids/probiotics/faecal microbiota transplantation引用本文复制引用
出版年
2024
NETL
NSTL
维普
万方数据