Effects of gut microbiome and metabolites on metabolic dysfunction associated fatty liver disease
In 2020 an international panel of experts recommended that non-alcoholic fatty liver disease be renamed metabolic dysfunction associated fatty liver disease(MAFLD)and proposed a new set of positive diagnostic criteria.The pathophysiology of MAFLD involves a variety of factors such as environment,genetics,metabolism,and gut microbiome.Microbe-derived metabolites may play an important role in the development of MAFLD.This article reviews the mechanisms of bile acids,short-chain fatty acids,tryptophan,choline,endotoxin,and ethanol as gut microbiota metabolites leading to the development of MAFLD and related treatment progress.
gut microbiomemetabolic dysfunction associated fatty liver diseasebile acidsprobioticsfaecal microbiota transplantation
NETL
NSTL
万方数据
维普
