Correlation analysis of homocysteine and type 2 diabetes mellitus with mild cognitive impairment in middle-aged and elderly patients
Objective:To investigate the relationship between homocysteine level and type 2 diabetes mellitus with mild cognitive impairment in middle-aged and elderly patients.Methods:A total of 121 middle-aged and elderly patients with type 2 diabetes who were admitted to the Department of Endocrinology of the Second Affiliated Hospital of Shandong First Medical University from November 1,2022 to September 30,2023 were selected.59 patients were divided into 59 cases of normal homocysteine group(≤15 μmol/L)and 62 were deivided into homocysteine elevated group(>15 μmol/L)according to the serum homocysteine level,Their cognitive function was assessed and compared according to the MMSE and ADL.Results:Compared with patients with normal homocysteine,patients with elevated homocysteine had a significantly higher rate of mild cognitive impairment,with a statistically significant difference(P<0.001).In the terms of the total score of MoCA scale,compared with the homocysteine normal group,the total score of MoCA scale in the homocysteine elevated group was significantly lower,and the difference was statistically significant(P<0.001).In the terms of visual space and executive function,naming,delayed recall,the scores of patients of the homocysteine elevated group were significantly lower than that of the homocysteine normal group,the difference was statistically significant(P<0.001).In the terms of attention,language and orientation,patients of the homocysteine elevated group scored significantly lower than the homocysteine normal group,the difference was statistically significant(P<0.05).In the terms of abstraction,there was no statistically significant difference in the scores of patients between the homocysteine normal group and the homocysteine elevated group(P>0.05).Conclusion:1.Homocysteine is negatively correlated with the total score of the Montreal Cognitive Function Assessment Scale,and it is a risk factor for type 2 diabetes with mild cognitive impairment.2.Elevated plasma homocysteine had significant effects on visuospatial and executive function,naming,delayed recall,attention,language,and orientation,especially on naming and delayed recall,but had no effect on abstract function.
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