Relationship between intestinal flora imbalance and severe acute pancreatitis
Acute pancreatitis(AP)is one of the most clinically common acute abdominal disorders,with 10 to 20 percent progressing to severe acute pancreatitis(SAP),which has a high mortality rate,rapid morbidity,and varied complications.There are two peaks in the death of SAP patients,the first peak occurs earlier and is associated with high mortality caused by systemic inflammatory response syndrome within two weeks of onset,and the second peak is associated with middle and late intestinal barrier damage and sepsis caused by bacterial displacement.High mortality in the middle and late stages of SAP is closely related to intestinal barrier damage and intestinal flora imbalance,and some important bacteria and its metabolites may become an important basis for diagnosis or even a target for disease treatment.Through consulting PubMed,Medline,CNKI and other databases,this paper further elaborated and summarized the relationship between intestinal flora and SAP,providing more possibilities for the treatment of SAP.
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