肺癌免疫治疗新靶点:中性粒细胞胞外诱捕网
A new target for immunotherapy of lung cancer:neutrophil extracellular trapping networks
赵洪珍 1孔令欣 1汪增明 2赵斌 1段国辰3
作者信息
- 1. 河北省人民医院胸外科,河北 石家庄 050057;河北医科大学研究生院,河北 石家庄 050017
- 2. 河北省人民医院胸外科,河北 石家庄 050057;河北北方学院研究生院,河北 张家口 075132
- 3. 河北省人民医院胸外科,河北 石家庄 050057
- 折叠
摘要
肺癌是我国居民发病率和死亡率都较高的恶性肿瘤之一,了解其发生和发展的机制以便采取更好的策略进行预防和治疗尤为重要.肿瘤相关微环境在肿瘤的发生、发展中起着重要作用,肿瘤相关的中性粒细胞代表着肿瘤微环境中的大部分炎性细胞,中性粒细胞能够分泌一种网状结构称为中性粒细胞胞外诱捕网(neutrophil extracellular trapping networks,NETs),然而,NETs促进肿瘤发生、发展的相关机制尚不清楚,本综述着重讨论了其在肺癌发生、发展中所起的关键作用.
Abstract
Lung cancer is one of the malignant tumors with high morbidity and mortality in China.Therefore,it is particularly important to understand the mechanisms of its occurrence and development in order to adopt better strategies for prevention and treatment.The tumor-associated microenvironment plays an important role in the development of tumors,and tumor-associated neutrophils represent most inflammatory cells in the tumor microenvironment.Neutrophil extracellular trapping networks(NETs)is a network structure secreted by neutrophils.However,the mechanism which NETs promote the occurrence and development of lung cancer remains unclear,and this review focuses on the important role which plays in the development of lung cancer.
关键词
肺癌/中性粒细胞胞外诱捕网/中性粒细胞/炎症Key words
lung cancer/neutrophil extracellular trapping networks/neutrophil/inflammation引用本文复制引用
出版年
2024
NETL
NSTL
万方数据