Clinical significance of SOX10 expression in triple negative breast cancer and correlation with EMT
Objective:To investigate the clinical significance of SOX10 expression in triple negative breast cancer(TNBC)tissues and its correlation with epithelial-mesenchymal transition(EMT).Methods:To use Immunohistochemical methods to detect the expression levels of SOX10 protein in 80 cases of TNBC and 60 cases of non TNBC tissues,as well as the expression levels of EMT key markers Vimentin and E-cadherin in TNBC tissues and to analyze the relationship between SOX10,Vimentin and E-cadherin in TNBC and clinicopathological parameters and the correlation between SOX10 and EMT markers.Results:SOX10 expression was significantly higher in TNBC than that in non-TNBC(P<0.001).The expression of SOX10 was associated with tumor classification,histological grade,Ki67 high value-added expression(Ki67≥30%)and lymph node metastasis in TNBC patients(P<0.05),and has no relationship with age or tumor diameter.The expression of SOX10 was positively correlated with Vimentin expression(r=0.398,P<0.001)and negatively correlated with E-cadherin expression(r=-0.337,P<0.01).Conclusion:SOX10 is specifically and highly expressed in TNBC and can be used as a useful biological marker for the differential diagnosis and prognosis of TNBC.SOX10 may promote tumor invasion and metastasis by regulating the expression of EMT-related proteins.
SOX10triple-negative breast cancerepithelial-mesenchymal transitionvimentinE-cadherin
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