Transient receptor potential channel vanilloid 3(TRPV3)is a Ca2+permeable channel,located in plasma membrane.Except physical regulation of warmth(≥32℃),the activity of TRPV3 is regulated by various endogenous and exogenous chemicals.With these chemicals,recent studies reveal physiological and pathological functions of TRPV3 including temperature sensing,hair growth,pain transduction,and skin inflammation,suggesting that TRPV3 is a potential drug development target.This article reviews the research progress of TRPV3 modulators,providing reference for subsequent researches on TRPV3.
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