The standard treatment of locally advanced rectal cancer(LARC)is the mode of neoadjuvant chemoradiotherapy(CRT)followed by total mesorectal excision(TME)plus adjuvant chemotherapy(ACT).Neoadjuvant therapy significantly improves prognosis.However,the rate of distant metastasis is still kept high.The usual neoadjuvant chemotherapy is FOLFOX or FOLFIRI two-drug regimens,while FOLFOXIRI three-drug regimen remains stronger.This article has summarized the application of three-drug chemotherapy in neoadjuvant therapy for LARC,hoping to provide reference for clinical diagnosis and treatment.
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