首页|非编码RNA在糖尿病心肌病早期诊断中的价值

非编码RNA在糖尿病心肌病早期诊断中的价值

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糖尿病心肌病(diabetic cardiomyopathy,DCM)的患病率逐年增加,也是糖尿病患者死亡和残疾常见的原因.特点主要为舒张功能障碍和心脏重构,疾病进展缓慢,早期缺乏明显的症状,故早期诊断比较困难.目前针对DCM的诊断方法主要包括超声心动图、磁共振成像等影像学技术及利钠肽、脑利钠肽等生物标志物的检测,然而尚缺乏特异性.本文总结了非编码RNA(non-coding RNA,ncRNA)作为潜在生物标志物的研究进展及目前的局限性,旨在为DCM的早期诊断提供一些线索.
The value of non-coding RNA in the early diagnosis of diabetic cardiomyopathy
The prevalence of diabetic cardiomyopathy is gradually increasing each year,and it is currently the most common cause of death and disability in diabetic patients.It is characterized mainly by diastolic dysfunction and cardiac remodeling,slow progression,and a lack of obvious symptoms in the early stage,which makes early diagnosis difficult.Currently,the main techniques employed in the diagnosis of diabetic cardiomyopathy include imaging techniques such as echocardiography and magnetic resonance imaging,as well as biomarkers such as natriuretic peptide and brain natriuretic peptide.However,these techniques are short of specificity.This paper summarizes the research progress and current limitations of non-coding RNA as a potential biomarker with the aim of providing some clues for the early diagnosis of diabetic cardiomyopathy.

diabetic cardiomyopathynon-coding RNAbiomarkerearly diagnosis

苏娜、张新焕、王燕、路坤娜、曹铭锋

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山东第一医科大学(山东省医学科学院)研究生部,山东 济南 250117

山东第一医科大学第二附属医院内分泌科,山东 泰安 271000

糖尿病心肌病 非编码RNA 生物标志物 早期诊断

2024

山东第一医科大学(山东省医学科学院)学报
泰山医学院

山东第一医科大学(山东省医学科学院)学报

影响因子:0.6
ISSN:2097-0005
年,卷(期):2024.45(10)