Characteristics of serum IgG N-glycosylation in neonatal patients with respiratory distress syndrome
Objective:Neonatal respiratory distress syndrome(NRDS)is a significant contributor to neonatal mortality,necessitating a thorough investigation into its pathogenesis and the development of more effective clinical diagnostic and treatment strategies.This research aims to provide a fresh perspective on NRDS diagnosis and treatment by examining variations in serum IgG N-glycosylation.Methods:The study,conducted between December 2021 and September 2022 at Tai'an Maternal and Child Health Hospital,enrolled 67 NRDS patients and 70 control neonates who met the diagnostic criteria and inclusion criteria with informed guardian consent.Serum IgG N-glycosylation levels were quantitatively and qualitatively assessed using Ultra Performance Liquid Chromatography(UPLC)with a fluorescence detector.Statistical analyses,including t-tests,chi-square test,Wilcoxon rank sum tests,and binary logistic regression,were utilized to evaluate differences in basic characteristics,clinical indicators,and glycosylation modifications between the study groups.Results:The findings indicated that γ-Glutamyl Transferase(GGT)levels were an independent risk factor for NRDS occurrence among clinical biochemical indicators(OR=1.014,P=0.032).UPLC analysis revealed significant differences in the area percentages of specific glycans between NRDS children and the control group,even after adjusting for GGT levels.Conclusion:Notably,the study identified lower levels of dicalactosylation and dicalactosylation of core fucosylation in NRDS children,suggesting their potential involvement in NRDS development.In conclusion,elevated GGT levels are associated with an increased risk of NRDS,while alterations in specific glycan structures may play a role in the pathogenesis of NRDS.
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