Study of the value of preoperative NPR combined with psoas muscle index in patients undergoing colorectal cancer surgery
Objective:To investigate the prognostic value of neutrophil to pro-albumin ratio(NPR)combined with psoas index(PMI)in patients after colorectal cancer.Methods:Complete clinical data,laboratory test results,and computed tomography images were collected from 255 patients undergoing colorectal cancer resection.Differences in clinicopathological characteristics between groups were analyzed by chi-square test or Fisher's exact test,and NPR and PMI survival curves were drawn by Kaplan-Meier,and prognosis was compared by the Log rank method.The effect on overall survival was analyzed using Cox proportional hazards regression(OS)and a prognostic score model based on NPR and PMI.The ROC curve was used to compare the prognostic score model with NPR,PMI and TNM stage.Results:In the survival analysis,high NPR and low PMI showed significant differences in 1-year survival rates(P<0.05).The results of multivariate Cox prognosis analysis showed that CEA,CA125,SII,NPR,PMI,lymph node metastasis,distant metastasis,postoperative complications,TNM stage,and prealbumin were all independent risk factors affecting the overall survival of colorectal cancer.The prognostic prediction model based on CEA,CA125,SII,NPR,and PMI 5 independent risk factors,the ROC curve to predict colorectal cancer prognosis at 12 months was better than NPR and PMI alone,and better than the predictive power of TNM staging model.Conclusion:The prognostic prediction model constructed in this study can predict the 1-year survival rate of colorectal cancer patients.
psoas muscle indexneutrophilprealbuminprognosiscolorectal cancer
万方数据
维普
