摘要
乳腺癌(breast cancer,BC)是女性最常见的恶性肿瘤之一,也是导致死亡的主要原因.目前,BC治疗涉及手术、放疗、化疗等多学科方法.蒽环类、紫杉烷类以及5-氟尿嘧啶等化疗药物,广泛应用于BC的治疗,可显著降低死亡和复发的风险.但多种复杂因素引起的化疗耐药严重影响临床药物治疗效果,导致患者预后不良.这些药物耐药机制复杂,尚未完全阐明.非编码RNA主要包括微小RNA、长链非编码RNA、环状RNA等.不同类型的化疗药物和非编码RNA相互调节,复杂的联系在一起,精确介导BC的化疗耐药.本综述详细阐述了不同化疗药物耐药中涉及的非编码RNA,以期为BC的治疗提供新的潜在靶点.
Abstract
Breast cancer(BC)is one of the most common malignant tumors in women and is also a major cause of death.Currently,BC treatment involves a multidisciplinary approach,including surgery,radiotherapy,chemotherapy,and so on.Anthracyclines,taxanes,and 5-fluorouracil,among other chemotherapeutic drugs,are widely used in the treatment of BC and can significantly reduce the risk of death and recurrence.However,chemoresistance caused by various complex factors severely affects the clinical efficacy of drug treatment,leading to poor prognosis for patients.The mechanisms of drug resistance to these medications are complex and not yet fully elucidated.Non-coding RNA mainly includes microRNA,long non-coding RNA,circular RNA,etc.Different types of chemotherapeutic drugs and non-coding RNAs regulate and interact with each other in a complex manner,intricately linked to precisely mediate chemoresistance in BC.In this review,the involvement of non-coding RNA in drug resistance to different chemotherapy drugs is detailed,with the hope of providing new potential targets for the diagnosis and treatment of BC.
维普
万方数据