Research progress of non-coding RNA in chemotherapeutic drugs for breast cancer
Breast cancer(BC)is one of the most common malignant tumors in women and is also a major cause of death.Currently,BC treatment involves a multidisciplinary approach,including surgery,radiotherapy,chemotherapy,and so on.Anthracyclines,taxanes,and 5-fluorouracil,among other chemotherapeutic drugs,are widely used in the treatment of BC and can significantly reduce the risk of death and recurrence.However,chemoresistance caused by various complex factors severely affects the clinical efficacy of drug treatment,leading to poor prognosis for patients.The mechanisms of drug resistance to these medications are complex and not yet fully elucidated.Non-coding RNA mainly includes microRNA,long non-coding RNA,circular RNA,etc.Different types of chemotherapeutic drugs and non-coding RNAs regulate and interact with each other in a complex manner,intricately linked to precisely mediate chemoresistance in BC.In this review,the involvement of non-coding RNA in drug resistance to different chemotherapy drugs is detailed,with the hope of providing new potential targets for the diagnosis and treatment of BC.