加用氟哌噻吨美利曲辛片治疗肠易激综合征伴抑郁焦虑的疗效
Effect of Addition of Flupentixol and Melitracen Tablets on Irritable Bowel Syndrome with Depression and Anxiety
黄海辉 1吴建国1
作者信息
- 1. 广东省河源市源城区人民医院消化内科 517000
- 折叠
摘要
背景：精神心理因素在功能性胃肠病中起重要作用，抑郁焦虑等情感障碍与肠易激综合征（ IBS）可能有着共同的发病机制，故抗抑郁焦虑在IBS治疗中越来越被重视。目的：评价加用氟哌噻吨美利曲辛片治疗IBS伴抑郁焦虑的疗效。方法：将60例IBS伴抑郁焦虑患者随机分为对照组和治疗组。对照组予枯草杆菌二联活菌肠溶胶囊和马来酸曲美布汀，治疗组在此基础上加服氟哌噻吨美利曲辛片，疗程均为8周。治疗前后分别行汉密尔顿抑郁、焦虑量表以及症状评分。结果：与对照组相比，治疗组患者抑郁焦虑明显改善（ P<0.05）；腹痛、腹泻的有效率明显升高（P<0.05）；症状总评分显著降低（P<0.05）；治疗总有效率显著升高（93.3%对76.7%，P<0.05）；而不良反应发生率无明显差异。结论：加用氟哌噻吨美利曲辛片可明显提高IBS伴抑郁焦虑的疗效。
Abstract
Background:Psychological factor plays an important role in the pathogenesis of functional gastrointestinal disorders. Depression,anxiety may share the pathogenesis with irritable bowel syndrome( IBS),therefore,more and more attention has been paid to anti-depression and anti-anxiety in the treatment of IBS. Aims:To evaluate the effect of addition of flupentixol and melitracen tablets on IBS with depression and anxiety. Methods:Sixty IBS patients with depression and anxiety were randomly divided into control group and treatment group. Patients in control group were given live combined Bacillus subtilis and Enterococcus faecium enteric-coated capsules and trimebutine maleate,while paitents in treatment group were received flupentixol and melitracen tablets in addition to the above-mentioned medicine. Treatment course was 8 weeks. Hamilton depression scale,Hamilton anxiety scale and symptom score were evaluated before and after treatment. Results:Compared with control group,depression and anxiety in treatment group were obviously improved(P<0. 05);the relief rates of abdominal pain and diarrhea were significantly increased( P <0. 05 );and the total symptom score were significantly decreased(P<0. 05);the total effective rate was significantly increased(93. 3% vs. 76. 7%,P<0. 05). However,no significant difference in incidence of adverse reaction was found between the two groups. Conclusions:Additon of flupentixol and melitracen tablets can significantly improve the curative effect on IBS with depression and anxiety.
关键词
肠易激综合征/抑郁/焦虑/氟哌噻吨美利曲辛片/治疗Key words
Irritable Bowel Syndrome/Depression/Anxiety/Flupentixol And Melitracen/Therapy引用本文复制引用
出版年
2014
NETL
NSTL
维普
万方数据