Background:Doxycycline can be used in the eradication of Helicobacter pylori(Hp)infection,but there is a lack of large sample study to confirm its efficacy and safety.Aims:To explore the efficacy and safety of doxycycline in the eradication of Hp infection.Methods:Literatures on doxycycline and other antibiotics in the eradication of Hp infection were retrieved from CNKI,Wanfang data,VIP,PubMed,Embase,Web of Science,and Cochrane Library from the date of database establishment to October 2023.Meta-analysis was conducted by RevMan 5.3 software.Results:Nineteen literatures including 3 686 patients with Hp infection were enrolled.Both intention-to-treat(ITT)eradication rate(82.51%vs.73.65%;OR=1.72,95%CI:1.42-2.07,P<0.000 01)and per-protocol(PP)eradication rate(88.96%vs.78.06%;OR=1.63,95%CI:1.28-2.06,P<0.000 1)of doxycycline-based regimen were significantly higher than those of non-doxycycline regimens.The adverse reaction rate of doxycycline-based regimen was significantly lower than that of non-doxycycline regimens(8.35%vs.15.01%;OR=0.55,95%CI:0.42-0.71,P<0.000 01).Subgroup analysis showed that Hp eradication rate of doxycycline-based regimen was significantly higher than that of clarithromycin-based regimen(OR=2.67,95%CI:1.84-3.88,P<0.000 01)and levofloxacin-based regimen(OR=2.20,95%CI:1.50-3.22,P<0.000 1),however,no significant difference in Hp eradication rate was found between doxycycline-based regimen and amoxicillin-based regimen(OR=1.09,95%CI:0.78-1.52,P=0.61)and tetracycline-based regimen(OR=0.87,95%CI:0.33-2.26,P=0.77).Conclusions:The eradication rate of doxycycline-based regimen in the eradication of Hp is significantly higher than that of non-doxycycline regimens,and the adverse reaction rate is low,which is worthy of clinical application.
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