抗Hu抗体对胃肠动力障碍性疾病神经系统损伤机制的研究进展

Progress in Pathogenesis of Nervous System Injury in Gastrointestinal Motility Disorders Caused by Anti-Hu Antibody

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中文摘要：越来越多的研究提示靶向神经元抗体特别是抗Hu抗体可对中枢神经系统和(或)肠神经系统造成不同程度的损伤,影响相关疾病的发生、发展和预后,因此明确这类抗体对神经系统损伤的机制及其与疾病的相关性对个体化诊断和治疗具有重要指导意义.本文就抗Hu抗体与副肿瘤性胃肠动力障碍性疾病、慢性假性肠梗阻、肠易激综合征等疾病的相关性及其对神经元的损伤机制作一综述.

外文摘要：More and more studies suggest that targeting neuronal antibodies,particularly anti-Hu antibody,can cause various degrees of damage to central nervous system and/or enteric nervous system and affect the occurrence,progression,and prognosis of related diseases.Therefore,elucidating the mechanisms of anti-Hu antibody-induced nervous system injury and its relevance to diseases is of significant importance for individualized diagnosis and treatment.This article reviewed the associations between anti-Hu antibody and paraneoplastic gastrointestinal dysmotility,chronic intestinal pseudo-obstruction,and irritable bowel syndrome,as well as the mechanisms of neuronal damage caused by anti-Hu antibody.

外文关键词：

Anti-Hu AntibodyNervous System InjuriesGastrointestinal Motility DisordersParaneoplastic Syndromes,Nervous SystemIntestinal Pseudo-ObstructionIrritable Bowel Syndrome

作者：

付铭玉、方秀才

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作者单位：

中国医学科学院北京协和医学院北京协和医院消化内科(100730)

关键词：

抗Hu抗体神经系统损伤胃肠动力障碍副肿瘤综合征,神经系统肠假性梗阻肠易激综合征

基金：

国家重点研发计划课题

项目编号：

2022YFC2504004

出版年：

2024

DOI：

10.3969/j.issn.1008-7125.2024.02.006

胃肠病学

上海交通大学医学院附属仁济医院

胃肠病学

CSTPCD

影响因子：1.217

ISSN：1008-7125

年,卷(期)：2024.29(2)