Burden of Gastroesophageal Reflux Disease in China from 1990 to 2021
Background:Gastroesophageal reflux disease(GERD)is increasing in incidence worldwide,which has a significant impact on patients'quality of life and public health.Aims:To assess the trend dynamics of disease burden of GERD in China between 1990 and 2021.Methods:The Global Burden of Disease(GBD)2021 database was used to obtain the data on prevalence,incidence,and years lived with disability(YLDs)of GERD in China from 1990 to 2021.The age-period-cohort(APC)model was further used to quantitatively analyze the effects of age,period,and birth cohort on disease burden.Results:From 1990 to 2021,the prevalent cases,incident cases,and YLDs of GERD in China showed an increasing trend.However,the age-standardized prevalence,incidence,and YLDs rates in 2021 were 4 540.66/100 000,1 844.31/100 000 and 35.12/100 000,respectively,which decreased by 0.48%,0.40%and 0.43%,respectively compared with those in 1990.In analysis of sex groups,the age-standardized rates were basically consistent with the general trend,and the disease burden of women was higher than that of men.When stratified with ages,the prevalence,incidence,and YLDs rates increased with age in both general and sex groups,and reached the peak in elderly people.APC analysis demonstrated that from 1990 to 2021,the prevalence,incidence,and YLDs rates of GERD increased with age,and the longitudinal age curve showed a trend of first rising and then decreasing.The period effect showed a downward trend in rate ratio between 1992 and 2011,followed by an increase.The birth cohort effect showed a fluctuating decline in risk ratio generally,with roughly the same trend for men and women.Conclusions:Despite the decline in age-standardized rates of prevalence,incidence,and YLDs of GERD in China in recent years,the overall burden of disease is on the rise,especially among middle-aged and elderly people,who are at high risk of developing GERD.The prevention and treatment of GERD in China still faces serious challenges.
Gastroesophageal Reflux DiseaseDisease BurdenPrevalenceIncidenceYears Lived With DisabilityAge-Period-Cohort Model
NETL
NSTL
万方数据
