T cell immunoglobulin and mucin domain-containing protein 3(TIM-3)is a newly discovered inhibitory immune checkpoint receptor molecule that is widely expressed on the surface of immune cells and plays a vital inhibitory role in both innate and adaptive anti-tumor immunity.TIM-3 can be expressed on the surface of tumor cells,directly facilitating the occurrence and progression of tumor.TIM-3 is closely related to the occurrence,metastasis,prognosis and treatment of colorectal cancer by acting on various cells in the tumor microenvironment and promoting the formation of tumor-suppressive microenvironment.TIM-3 can serve as a molecular target for prognosis and immunotherapy of colorectal cancer,enhancing the application value of immunotherapy in colorectal cancer.This article reviewed the expression and potential mechanism of TIM-3 in the tumor microenvironment of colorectal cancer and its correlation with the prognosis and treatment of colorectal cancer.
关键词
T细胞免疫球蛋白黏蛋白3/结直肠肿瘤/配体/T淋巴细胞/巨噬细胞/树突细胞/免疫疗法
Key words
T Cell Immunoglobulin and Mucin Domain-Containing Protein 3/Colorectal Neoplasms/Ligands/T-Lymphocytes/Macrophages/Dendritic Cells/Immunotherapy
维普
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