首页|血清胆汁酸在胃肠道疾病中的研究进展

血清胆汁酸在胃肠道疾病中的研究进展

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胆汁酸是参与脂质消化吸收的重要分子,在肝脏合成后被输送至肠道中发挥作用,主要分布于胆囊、肝脏、胃肠道和外周血中.众多研究表明胆汁酸参与了肠易激综合征、炎症性肠病、消化道肿瘤等多种胃肠道疾病的发生、发展,血清胆汁酸被广泛应用于肝功能监测、肝病诊断、预后评估等方面.本文就胆汁酸的生理功能和代谢异常的病理生理,以及血清胆汁酸与胃肠道疾病的研究进展进行总结分析,为进一步探索其应用于胃肠道疾病的临床诊断和评估提供参考.
Research Progress of Serum Bile Acids in Gastrointestinal Diseases
Bile acids are synthesized in the liver and then transported to the intestine,playing important roles in the digestion and absorption of lipids.They are mainly distributed in the gallbladder,liver,gastrointestinal tract and peripheral blood.Many studies have shown that bile acids are involved in the development of various gastrointestinal diseases,including irritable bowel syndrome,inflammatory bowel disease,and gastrointestinal tumors.Serum bile acids have been widely used in the liver function monitoring,liver diseases diagnosis,and prognosis assessment.This article summarized and analyzed the physiological functions and pathophysiology of abnormal metabolism of bile acids,and the research progress of serum bile acids and gastrointestinal diseases,in order to provide a reference for further exploration of their application in clinical diagnosis and evaluation of gastrointestinal diseases.

Bile AcidsIrritable Bowel SyndromeInflammatory Bowel DiseaseDigestive System NeoplasmsBiomarkers

姚诺、时永全

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空军军医大学第一附属医院消化内科(710032)

胆汁酸 肠易激综合征 炎症性肠病 消化系统肿瘤 生物学标志物

2024

胃肠病学
上海交通大学医学院附属仁济医院

胃肠病学

CSTPCD
影响因子:1.217
ISSN:1008-7125
年,卷(期):2024.29(5)