Objective To investigate the potential prognostic value of necroptosis-related miRNA and their relationship with the tumor microenvironment(TME)in GC.Methods miRNA sequencing and clinical data related to gastric adenocarcinoma(STAD)were downloaded from the Cancer Genome Atlas database.First,necroptosis-related miRNAs were identified via co-expression and differential expression analysis of miRNA and necroptosis-related genes.Subsequently,a univariate Cox regression analysis was employed to screen for prognostic STAD miRNAs.Furthermore,multivariate Cox regression analysis was used to establish the optimal prognostic risk model.The Kaplan-Meier method,nomogram,clinicopathological correlation analysis,and receiver operating characteristic curve are used to evaluate the miRNA prognostic ability.Results Four differentially expressed miRNAs(miR-885-5p,miR-1306-3p,miR-29c-5p,and miR-148a-5p)were obtained from a database for modeling.The risk score generated by the four miRNAs divided patients into high-and low-risk groups.The patients in the high-risk group had worse prognoses than those in the low-risk group.The area under the curve values for predicting the 1,3,and 5-year survival time were 0.707,0.705,and 0.761,respec-tively.Conclusion The study identified four necroptosis-related miRNAs that predicted the prognosis of STAD.These miRNAs may serve as an independent prognostic markers for STAD.
维普
万方数据