Objective To compare the clinical data between closed negative pressure drainage following open debridement of spinal infection lesions and conventional negative pressure drainage after debridement under inter-vertebral foramen endoscopy,and to determine the efficacy of closed negative pressure drainage in treating spinal infec-tion.Methods From January 2018 to June 2023,our hospital admitted 35 patients with spinal infection who were then divided into two groups according to the surgical method:a closed negative pressure drainage group(VSD group;20 ca-ses)and a regular negative pressure drainage group(GPD group;15 cases).Analyze and compare the progress of two groups of patients during hospitalization,such as the rate of normal body temperature 3 days post-surgery,changes in in-flammatory indicators 7 days post-surgery,total drainage volume 5 days post-surgery,drainage tube retention time,and functional scores 15 days post-surgery,and perform statistical analysis.Results After different methods of debridement and drainage,symptoms and indicators improved to various degrees in 35 patients.The VSD group underwent general an-esthesia with posterior lumbar approach for open surgery,which caused more trauma and resulted in less significant im-provement of inflammatory indicators such as C-reactive protein and erythrocyte sedimentation rate compared to the GPD group within 7 days after surgery.However,through thorough drainage,the VSD group was able to effectively relieve fever symptoms in patients(P<0.05).The Visual Analog Scale(VAS)at 15 days post-surgery revealed a significant advantage for the VSD group compared to the GPD group(P<0.05).Conclusion Compared to the GPD group,the VSD group had a more thorough drainage,which resultes in a better short-term improvement of symptoms after surgery,but with a greater risk of surgical trauma.