Objective To investigate the effect of the time interval from the last intramuscular injection of antenatal corticosteroids(ACS)administration to delivery on the main complications of preterm infants.Methods A ret-rospective analysis of 300 premature infants hospitaled in the Neonatal Intensive Care Unit of Weifang People's Hospital from April 2020～April 2023 with a gestational age of 28 weeks to 33+6 weeks was performed.The time interval from glu-cocorticoid to delivery was divided into＜48h group(105 cases),～7 days group(141 cases)and＞7 days group(54 ca-ses).The major complications were compared among the three groups.Univariate Logistic regression was used to analyze the effect of gestational age on major complications of preterm infants.Results There were significant differences in ges-tational age and the rate of invasive mechanical ventilation among the three groups,and there were significant differences between the two groups.The incidence of neonatal respiratory distress syndrome(NRDS)was significantly different a-mong the three groups,and the two groups were significantly different.There were significant differences between the two comparisons(P＜0.05),and there were no significant difference in the incidence of other clinical complications,inclu-ding Necrotizing Enterocolitis(NEC),Bronchopulmonary Dysplasia(BPD),sepsis,and metabolic acidosis(P＞0.05).Univariate Logistic regression analysis showed that the gestational age was an independent risk factor for NRDS.Conclu-sion The time interval from the last administration of ACS to delivery in a single course is correlated with the incidence of NRDS and the use rate of mechanical ventilation in premature infants.The interval from ACS to delivery＜48 hours is the optimal time window for medication,and gestational age is an independent risk factor for the occurrence of NRDS.
维普
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