Objective To explore the damage of sulfur dioxide derivatives in vivo to the genetic material of mice and evaluate the impact of sulfur dioxide on the genetic stability of organisms.Methods Forty-eight Kunming mice were selected as the research objects and randomly divided into 8 groups,with 6 mice in each group(half male and half female).The exposure reagent was a mixture of sodium sulfite and sodium bisulfite(molar ratio 3:1).Groups 1-4 were dose-module groups,with exposure doses of 150 mg/kg,350 mg/kg,550 mg/kg,and 750 mg/kg,respectively.Groups 5-7 were time-module groups,with exposure times of 36 h,48 h,and 60 h,respectively.Group 8 was the blank control group.Analysis of variance and t-tests were performed to compare the micronucleus rates of polychromatic erythrocytes a-mong different groups of mice.The Pearson method was used to analyze the correlations between various indicators.Re-sults There were significant differences in the micronucleus rates among different dose groups(P＜0.001).Multiple comparisons indicated that within a certain concentration range(＜550 mg/kg),the micronucleus rate increased with the increase in exposure dose(P＜0.001).After 36,48,and 60 hours of exposure,the micronucleus rates of mice were signif-icantly higher than those of the control group(P＜0.001).Multiple comparisons within the groups showed that with the prolongation of exposure time,the micronucleus rate first decreased and then increased(P＜0.001).Conclusion Sulfur dioxide derivatives in vivo can increase the micronucleus rate of polychromatic erythrocytes in mice and are positively correlated with the exposure dose and time.
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