Objective To explore the clinical application value and safety of clinical ultrasound-guided per-cutaneous lung biopsy and endobronchial ultrasound-guided sheath(EBUS-GS)techniques in the biopsy diagnosis of pe-ripheral pulmonary lesions.Methods From March 2022 to September 2023,182 patients with peripheral pulmonary nod-ules detected by chest CT in the Affiliated Hospital of Shandong Second Medical University,who required lung puncture for a definite diagnosis,were randomly divided into the EBUS-GS group(92 cases)and the ultrasound-guided percutane-ous lung biopsy group(90 cases).Before the operation,detailed information such as the size and location of the pulmona-ry lesions was recorded.The obtained specimens were pathologically diagnosed.Those with a clear pathological diagnosis were regarded as satisfactory sampling,while those with negative or undetermined pathological results were considered as unsatisfactory sampling.Post-operative follow-up was conducted,and the occurrence of relevant complications was recor-ded in detail.Results The EBUS-GS group had slightly higher rates of satisfactory sampling and successful sampling than the ultrasound-guided percutaneous lung biopsy group,but the difference was not statistically significant(P＞0.05).The diagnostic accuracy rate of the EBUS-GS group was significantly higher than that of the ultrasound-guided percutane-ous lung biopsy group(x2=5.325,P=0.029),and the false-negative rate was lower than that of the ultrasound-guided percutaneous lung biopsy group(x2=8.395,P＜0.001).Compared with the EBUS-GS group,patients in the ultrasound-guided percutaneous lung biopsy group had a significantly increased risk of hemoptysis and intrapulmonary hemorrhage after puncture,and the difference was statistically significant(P＜0.05).Moreover,the number of puncture times ≥3 and the distance of the lesion from the chest wall ≥ 1 cm were independent risk factors for intrapulmonary hemorrhage in the ultrasound-guided percutaneous lung biopsy group.Conclusion Both the endobronchial ultrasound-guided sheath(EBUS-GS)technique and the ultrasound-guided percutaneous lung biopsy technique can safely and effectively diagnose peripheral pulmonary space-occupying lesions.However,EBUS-GS has more advantages in terms of biopsy accuracy and safety for peripheral pulmonary lesions.
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