Taking the first high-speed railway station in China passing through with a mainline speed of 350 km/h as the research object,the train-station CFD model and the train-viaduct-foundation soil dynamics model were established to calculate the pulsating wind pressure and ground vibration load respectively,which were used as inputs to the finite ele-ment model of the station.After verifying the accuracy of the models through analogical tests,the vibration comfort of the superstructure was analyzed.The results show that,the peak wind pressure of the 350 km/h train on the floor slab above is about 750 Pa,and the dynamic effect is significant.If the foundation of the mainline viaduct and the station building are close to each other and no vibration isolation measures are adopted,the vibration propagated by the foundation soil during the high-speed passage of the mainline train has a significant effect on the structure of the station building.The wind-vehi-cle excitation of the high-speed train results in the exceeding of the comfort level of the structure of the station building.