A layered calculation model was establised for sound barrier sandwich panel based on layered theory and ob-tained the mean square vibration velocity of the structure by vibration equations of sound barrier sandwich panels.The ra-diated sound power of the sound barrier sandwich panel was solved,which verified the feasibility proposed.Finally,the vi-bration-induced acoustic mechanism of the sound barrier sandwich panel was further explored and analyzed.The results show that the sandwich layer of the sound barrier sandwich panel has a significant impact on its modal characteristics,es-pecially its natural frequency.The simulation results obtained by neglecting the effect of the sandwich layer and simplify-ing the structure to a single-layer homogeneous thin plate structure have an obvious discrepancy with the measured val-ues.There is a corresponding relationship between the peak frequencies of sound radiation response and structural vibra-tion of sound barrier sandwich panel.Its sound radiation efficiency is not only related to the structural vibration mode and response,but also to the structural sound radiation response.The ability of radiating structural noise is enhanced with the improving of the structural sound radiation efficiency.