Multi-scale with ALE method was used to simulate the dynamic response and damage mode of 18-story frame-shear structure under car bomb attack based on the explicit finite element software LS-DYNA.The effects of differ-ent explosive distances and TNT amounts were investigated on the damage behavior of the high-rise frame-shear struc-ture,in which the TNT were placed on the middle column of long side and the front of the L-type shear wall.Then the fail modes of shear walls were compared.Results show that when the scaled distance is constant,a larger TNT equivalent weight and a greater distance from the source to the structure result in more severe damage.The damage degree of frame-shear wall structure under explosive loading is as follows:floor slab,shear wall,frame beam,and frame column.The bot-tom of a single shear wall is prone to bending-shear failure under car bomb attack,while the L-shaped shear wall is prone to bending failure under frontal explosion impact,and there are huge cracks in the corner.