This study aimed to investigate the regulatory effects of complex dietary fiber on blood glucose,blood lipids,short-chain fatty acids(SCFAs),and gut microbiota in diabetic mice.SPF-grade C57BL/6J mice were selected,with the control group fed a basal diet while the remaining mice were fed a high-sugar,high-fat diet for 8 weeks followed by intraperitoneal injection of streptozotocin(STZ)solution to induce di-abetes.The diabetic mice were randomly divided into model control group,low,medium,and high-dose complex dietary fiber groups.The control group continued on the basal diet,the model control group con-tinued on the high-sugar,high-fat diet,while the low,medium,and high-dose complex dietary fiber groups were fed a high-sugar,high-fat diet containing 2.5％,5.0％,and 7.5％composite dietary fiber,respective-ly,for 8 weeks.Afterward,the model control group switched to the basal diet,and the low,medium,and high-dose complex dietary fiber groups switched to a basal diet containing 2.5％,5.0％,and 7.5％complex dietary fiber,respectively,for 4 weeks.Blood glucose,blood lipids,SCFAs content,and gut microbiota com-position were assessed at the end of the feeding period.The results showed that complex dietary fiber could decrease fasting blood glucose levels,alleviate insulin resistance,and improve blood lipid abnormalities in diabetic mice.Additionally,complex dietary fiber could promote the secretion of acetic acid,propionic acid,butyric acid,pentanic acid,isobutyric acid,and isovaleric acid to some extent.It downregulated the relative abundance of Firmicutes,Rikenellaceae and Lachnospiraceae,pregulated Bacteroidotas relative abundance,reduced the F/B ratio.Complex dietary fiber effectively improved blood glucose and blood lipid levels in di-abetic mice,possibly through modulation of gut microbiota composition and promotion of SCFAs secretion.
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