The target and mechanism of selenide on pneumonia were analyzed by network pharmacology and molecu-lar docking technology.Pubchem,Swiss Target Prediction and other databases were used to screen common selenides and their targets,and then the pneumonia-related targets were obtained through GeneCards and TTD databases,and the common targets were obtained by the intersection of them.Protein interaction network diagram is obtained by u-sing String database,and the interaction relationship between targets and key targets are obtained;GO and KEGG pathways of key targets were enriched by Metascape database,and Cytoscape was used as the interaction network di-agram.Finally,the molecular docking was verified by AutoDock Vina.32 common selenides were screened out,and 79 common targets of selenides and pneumonia were found.Three key selenides(2-Methoxy-2-phenylpropyl)(phe-nyl)selenium,(4-acetyminophenyl)dihydroxy selenium and Se-Propylselenocysteine(PSC)and four core targets(STAT3,SRC,PTGS2 and MAPK3)were finally screened out through topological analysis and enrichment analysis of GO and KEGG pathways,and it was revealed that they could inhibit STAT3,PI3 K/MAPK3.The results of molec-ular docking show that the binding effect is good.Selenium has certain therapeutic effect on pneumonia,which lays a theoretical foundation for further exploring the mechanism of selenium in treating pneumonia.
network pharmacologyselenidespneumoniatargetenrichment analysismechanism of action
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