Effects of curcumin on growth,antioxidant,immunity and disease resistance of hybrid sturgeon
The aim of this experiment was performed to investigate the effects of feed supplementation with curcumin on growth,antioxidant,immunity,intestinal morphology,and resistance to Aeromonas hydrophila infection in hy-brid sturgeon(Acipenser baerii ♀ × Acipenser schrenckii ♂).Four hundred and eighty hybrid sturgeon(20.35±0.62 g)were randomly divided into four treatment groups,with three replicated experiments set up in each group and 40 fish in each experiment,and fed four diets with curcumin content of 0 mg/kg(C0 group),100 mg/kg(C1 group),300 mg/kg(C3 group),and 500 mg/kg(C5 group)for 8 weeks,respectively.The results showed that there were significant differences in final body weight,weight gain rate,specific growth rate and feed conversion rate of hybrid sturgeon in the curcumin-added group compared with the C0 group;lysozyme,acid phosphatase,al-kaline phosphatase and myeloperoxidase activities in serum of hybrid sturgeon from the curcumin-added group were higher than those of the unadded group;superoxide dismutase,hydrogen oxidase and glutathione peroxidase activi-ties were significantly higher and malondialdehyde content was significantly lower in the liver of fish fed curcumin diet.In addition,there was a tendency to increase the thickness of intestinal muscularis layer,height of villi and number of cup cells in hybrid sturgeon from curcumin-added group.The Aeromonas hydrophila infection test showed a significant reduction in the mortality rate of hybrid sturgeon in the curcumin-fed group,and the lowest cumulative mortality rate(30.00％)was observed in the C3-fed group.These results indicate that curcumin is suitable for use as an immune enhancer in hybrid sturgeon culture,and the recommended dosage is 300 mg/kg.The study can pro-vide theoretical basis and technical support for the application of curcumin in hybrid sturgeon feed supplementation.
万方数据
维普
