The aim of this experiment was performed to investigate the effects of feed supplementation with curcumin on growth,antioxidant,immunity,intestinal morphology,and resistance to Aeromonas hydrophila infection in hy-brid sturgeon(Acipenser baerii ♀ × Acipenser schrenckii ♂).Four hundred and eighty hybrid sturgeon(20.35±0.62 g)were randomly divided into four treatment groups,with three replicated experiments set up in each group and 40 fish in each experiment,and fed four diets with curcumin content of 0 mg/kg(C0 group),100 mg/kg(C1 group),300 mg/kg(C3 group),and 500 mg/kg(C5 group)for 8 weeks,respectively.The results showed that there were significant differences in final body weight,weight gain rate,specific growth rate and feed conversion rate of hybrid sturgeon in the curcumin-added group compared with the C0 group;lysozyme,acid phosphatase,al-kaline phosphatase and myeloperoxidase activities in serum of hybrid sturgeon from the curcumin-added group were higher than those of the unadded group;superoxide dismutase,hydrogen oxidase and glutathione peroxidase activi-ties were significantly higher and malondialdehyde content was significantly lower in the liver of fish fed curcumin diet.In addition,there was a tendency to increase the thickness of intestinal muscularis layer,height of villi and number of cup cells in hybrid sturgeon from curcumin-added group.The Aeromonas hydrophila infection test showed a significant reduction in the mortality rate of hybrid sturgeon in the curcumin-fed group,and the lowest cumulative mortality rate(30.00％)was observed in the C3-fed group.These results indicate that curcumin is suitable for use as an immune enhancer in hybrid sturgeon culture,and the recommended dosage is 300 mg/kg.The study can pro-vide theoretical basis and technical support for the application of curcumin in hybrid sturgeon feed supplementation.
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